SYNTHESIS, REACTIVITY, ANTI-OXIDANT AND CYTOTOXICITY EVALUATION OF SOME COUMARIN DERIVATIVES
Fekria M. A. Soliman, Zeinab H. Ismail, Nahed F. Abd El-Ghaffar, Nadia T. A. Dawood and Shaimaa H. Abd El Monem*
In the present work 3-amino-8-methoxy coumarin was prepared either by microwave irradiation or by convential method. It was used as a key starting material for the synthesis of triazole thione (8), Schiffs’ bases (10), thiazolone (11a-d), pyrimidinethione (13), aminothiazole (15) and isoxazole (18) derivatives through its reaction with different reagents. The structures of the newly synthesized compounds were elucidated on the basis of their elemental analysis and by using different spectroscopic methods. The free radical scavenging activity of some newly synthesized derivatives was determined by measuring their interaction with the stable free radical DPPH and some compounds have shown encouraging antioxidant activity. Also, they were screened for their in-vitro cytotoxicity against two human cancer cell lines namely HEIA cells (human cervical carcinoma) and A-549 cells (human lung cancer cell line). The IC50 values (the sample concentration that produces 50% reduction in cell growth) in μg/mL showed that some of the tested compounds exhibited significant cytotoxic effect.
Keywords: Coumarins, Microwave assisted, Green chemistry, Antioxidant, Cytotoxicity.
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