EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

SYNTHESIS, REACTIVITY, ANTI-OXIDANT AND CYTOTOXICITY EVALUATION OF SOME COUMARIN DERIVATIVES

Fekria M. A. Soliman, Zeinab H. Ismail, Nahed F. Abd El-Ghaffar, Nadia T. A. Dawood and Shaimaa H. Abd El Monem*

ABSTRACT

In the present work 3-amino-8-methoxy coumarin was prepared either by microwave irradiation or by convential method. It was used as a key starting material for the synthesis of triazole thione (8), Schiffs’ bases (10), thiazolone (11a-d), pyrimidinethione (13), aminothiazole (15) and isoxazole (18) derivatives through its reaction with different reagents. The structures of the newly synthesized compounds were elucidated on the basis of their elemental analysis and by using different spectroscopic methods. The free radical scavenging activity of some newly synthesized derivatives was determined by measuring their interaction with the stable free radical DPPH and some compounds have shown encouraging antioxidant activity. Also, they were screened for their in-vitro cytotoxicity against two human cancer cell lines namely HEIA cells (human cervical carcinoma) and A-549 cells (human lung cancer cell line). The IC50 values (the sample concentration that produces 50% reduction in cell growth) in μg/mL showed that some of the tested compounds exhibited significant cytotoxic effect.

Keywords: Coumarins, Microwave assisted, Green chemistry, Antioxidant, Cytotoxicity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)