EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTI-INFLAMMATORY PROPERTY OF NOVEL ISOINDOLE LEAD COMPOUNDS AND ESTIMATION OF LD50 OF THE MOST ACTIVE ENTITY

Madani A. M., Aimun A. E. Ahmed*, Tilal Elsaman, EI-Hadiyah T. M. and Hatem A. Abdel-Aziz

ABSTRACT

Background: Isoindole derivatives serve as an important source for lead compounds with numerous pharmacological uses. Objectives: The study aimed to investigate the anti-inflammatory property for newly synthesized six isoindole derivatives; TIND-1, TIND-7, TIND-10, TIND-11, TIND14 and TIND-15, and to estimate LD50 of most promising one. Methods: The carrageenan-induced paw edema model in rats used to investigate the anti-inflammatory activity of the tested compounds and to compare between them and the standard drug using inhibition of edema as a pharmacological parameter. Whilst the LD50 was estimated for TIND-7, using OEDC-AOT 425 guideline for acute oral toxicity on rats, in vivo. Results: All tested compounds exhibited various time-dependent anti-inflammatory activity, through different period of time; first hour, significant effect was revealed for TIND-14 (P<0.01) and TIND-15 (P<0.001), whilst at third hour, TIND-7 exhibited 71%, TIND-14 and TIND-15 demonstrated highest activity. Moreover, at fifth hour TIND-7 produced 100% inhibition. The estimated LD50 for the most active compound (TIND-7) was more than 2000 mg/kg. Conclusion: All tested compounds showed variety of anti-inflammatory activity against carrgenan-induced paw edema on rats, in vivo, however TIND-7 was the most promising compound ever, with reasonable margin of safety estimated as LD50.

Keywords: Anti-inflammatory, Isoindole, Paw-edema, Diclofenac, LD50, Protocol 425.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)