EFFECT OF ANTIOXIDANT VITAMINS AND MINERALS SUPPLEMENTATION ON THE RENAL FUNCTIONS AND HAEMATOLOGICAL INDICES OF ACUTE ISCHAEMIC STROKE SUBJECTS IN SOKOTO, NIGERIA

*Wali U., Saidu, Y., Isa S. A., Balarabe S. A., Abbas A. Y. and Bilbis L. S.

ABSTRACT

Acute ischaemic stroke (AIS) is characterized by renal and haematological indices impairements, which might have conspired to the development of the disease and its attendant complications. The current work studied the effect of antioxidant vitamins and minerals supplementation on serum renal functions and haematological indices in AIS subjects. A total of fourty two ischaemic stroke subjects presented within 72 hour of symptom onset were treated with conventional drug and supplemented with daily oral dose of 10 mg vitamin E, 60 mg of vitamin C, 700 IU of vitamin A, 3 mg of copper, 15 mg of zinc, 5 mg of manganese, 200 μg of chromium and 200 μg of selenium for 2 weeks. The results suggested that supplementation significantly (P<0.05) reduced serum urea, creatinine, potassium, white blood cell count and platelet count. Supplementation also significantly (P<0.05) increased serum sodium, chloride, red blood cell count and haemoglobin. The beneficial effect is more pronounced in a group supplemented with RDA X 1.5 of the antioxidant vitamins and minerals. It is concluded that supplementation with RDA/RDA X 1.5 of antioxidant vitamins and minerals may reduce the risk of renal and haematological impairements associated with acute ischaemic stroke.

Keywords: Antioxidant vitamins and minerals, acute ischaemic stroke.