THE EFFECTS OF RESVERATROL AND SULFORAPHANE ON THE REGULATION OF INOS/NRF2 PATHS IN THE OROFACIAL INFLAMMATION-INDUCED MODEL
Min-Kyoung Park, Min-Kyung Lee and Kyung-Yae Hyun*
This study aimed to identify the effect of resveratrol and sulforaphane on the regulation of inflammation in the orofacial inflammation-induced model. Orofacial inflammation was induced by injecting 5% formalin (50 μl) under the skin of the right side of the face of rats using an insulin syringe. Resveratrol and sulforaphane were found to suppress the secretion of IL-6 or IL-1β and regulate the expression of Nrf2 (or NFE2L2: Nuclear factor (erythroid-derived 2)-like 2), iNOS (inducible nitric oxide synthases) or Nox4 (NADPH oxidase 4). Resveratrol and sulforaphane seem to regulate pro-inflammatory cytokines (IL-6 or IL-1β) and iNOS/Nrf2, and thus to reduce and protect against orofacial inflammation.
Keywords: Resveratrol, Sulforaphane, Cytokine, iNOS, Nrf2.
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