EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF POLAXOMER COATED RETROVIRAL NANOPARTICLES

Chamala Aparna*, S. Chellaram and D. Dhachinamoorthi

ABSTRACT

Nanoparticulate delivery systems were found to be attractive mean in the treatment for various chronic diseases. The nanosize facilities improved bioavailability of poorly soluble drugs targeting to cancer to cancer cell to HIV infected cells. The main objective of this work was to investigate the ability of macromolecular protein. Bovine serum albumin (BSA) for functional carrier property to develop into nanoparticles. Lamivudine (LV) is an anti-retroviral drug and effectively to treat hepatitis B viral infections and also in the treatment of acquired immunodeficiency syndrome (AIDS) caused by Human immunodeficiency virus (HIV). In this study.LV was loaded into BSA solvent desolvation technique and the effect of process variable such as drug carrier ration, volume of cross linking agent, gluteraldehyde (GA) on the particle size, zeta- potential and in vitro release characteristics were studied. The particle size distribution of the formulation was in the range from 469-163nm. The entrapment efficiency and loading capacity of total of nine formulations (F1-F6) were in the range of 28-52% and 14-26%. The zeta potential of the formulation F5- was -27.8 than F6-21.4. the decreased surface charge could be attributed to high GA volumes whereas the in vitro release characteristics of F4-F6 extended for 64 hrs. From the study it was concluded that the method selected was able to effectively load the drug. The in vitro release characteristics found to exhibit better release retardation and prolonging the drug therapy and minimization of multiple doses.

Keywords: Lamivudine, Bovine Serum Albumin, Nanoparticles.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)