HEPATOPROTECTIVE EFFECT OF JATROPHA CURCAS FRUIT EXTRACTS AGAINST CARBON TETRACHLORIDE INDUCED LIVER FIBROSIS IN RATS
Andaluri Sowjanya*, G. Pitchaiah and D. Dhachinamoorthi
The present study was undertaken to explore the hepatoprotective potential of Jatropha curcas fruit extracts against carbon tetrachloride (CCl4) induced liver fibrosis in wistar rats. Liver fibrosis was induced by carbon tetrachloride (3ml/kg body weight) in animals. Blood biochemical, urine analysis and histological studies were carried to assess the hepatoprotective effect. Carbon tetrachloride administration induced severe liver fibrosis in rats, which was evident from enhanced levels of albumin, total bilirubin, direct bilirubin, indirect bilirubin, serum glutamate-O-methyl transferase, serum glutamate pyruvate transferase and alkaline phosphate. Pretreatment with silymarin (50mg/kg dose orally) significantly reversed carbon tetrachloride induced liver fibrosis. Jatropha curcas methanolic extract (250mg/kg body weight) showed significant effect than Jatropha curcas aqueous extract (250mg/kg body weight). From the obtained results it may be concluded that Jatropha curcas methanolic extract exerted a significant effect against CCl4 induced hepatotoxicity in rats than Jatropha curcas aqueous extract (p<0.001) for most of the blood biochemical, urine analysis as well in attenuation of liver fibrosis.
Keywords: Hepatoprotective, carbon tetrachloride, silymarin, Jatropha curcas, liver fibrosis.
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