EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HEPATOPROTECTIVE EFFECT OF JATROPHA CURCAS FRUIT EXTRACTS AGAINST CARBON TETRACHLORIDE INDUCED LIVER FIBROSIS IN RATS

Andaluri Sowjanya*, G. Pitchaiah and D. Dhachinamoorthi

ABSTRACT

The present study was undertaken to explore the hepatoprotective potential of Jatropha curcas fruit extracts against carbon tetrachloride (CCl4) induced liver fibrosis in wistar rats. Liver fibrosis was induced by carbon tetrachloride (3ml/kg body weight) in animals. Blood biochemical, urine analysis and histological studies were carried to assess the hepatoprotective effect. Carbon tetrachloride administration induced severe liver fibrosis in rats, which was evident from enhanced levels of albumin, total bilirubin, direct bilirubin, indirect bilirubin, serum glutamate-O-methyl transferase, serum glutamate pyruvate transferase and alkaline phosphate. Pretreatment with silymarin (50mg/kg dose orally) significantly reversed carbon tetrachloride induced liver fibrosis. Jatropha curcas methanolic extract (250mg/kg body weight) showed significant effect than Jatropha curcas aqueous extract (250mg/kg body weight). From the obtained results it may be concluded that Jatropha curcas methanolic extract exerted a significant effect against CCl4 induced hepatotoxicity in rats than Jatropha curcas aqueous extract (p<0.001) for most of the blood biochemical, urine analysis as well in attenuation of liver fibrosis.

Keywords: Hepatoprotective, carbon tetrachloride, silymarin, Jatropha curcas, liver fibrosis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)