EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

DEVELOPMENT OF DISCRIMINATORY DISSOLUTION METHOD OF EXTENDED RELEASE FORMULATION CONTAINING HIGHLY SOLUBLE DRUG

*Sanjay Kumar Sahu and Dr. Ashish Sharma

ABSTRACT

The aim of this work is to develop discriminating dissolution test methodology for metoprolol extended release tablets. LC Method was applied to test dissolution profile for extended release tablets containing 190 mg of metoprolol succinate. The appropriate conditions were determined after testing sink conditions in dissolution medium, rotation speed, pH of the dissolution medium, apparatus type and rotational speed. Dissolution profile was compared by model independent method. Based on studies conditions for this extended release formulation, the best dissolution conditions were achieved using a USP apparatus II, 900 ml of medium of pH 6.8 Phosphate buffer at a rotation speed of 150 rpm. Since there is monograph for this drug in tablets which is based on multiparticulate drug delivery system, the dissolution method presented here can be used as a quality control test for metoprolol extended release tablet matrix formulation with special emphasis to understand in a batch to batch evaluation.

Keywords: Metoprolol, Discrimination, dissolution, extended release.

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