EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTI-DIABETIC PROPERTIES OF LANNEA COROMANDELICA L. BARK EXTRACT ON ALLOXAN INDUCED TYPE-2 DIABETIC RATS

Rajibul Islam, Md. Abdus Sobahan Khan, Md. Sirazul Islam*, Sara Benozir and Md. Jahir Alam

ABSTRACT

Background: Diabetes is a major public health concern. Despite of continuous new drug development, diabetes and its related complications remains to be a major clinical problem. Medicinal plants are efficient ameliorator of oxidative stress associated with diabetes mellitus and herbal remedies remain a potential adjunct therapy to maintain better glycemic control with a few side-effects. The aim of the present study was to investigate the antidiabetic activities of Lannea coromandelica L. bark (LC) in alloxan induced type-2 diabetic rats. Methods: Diabetes was induced by a single dose of intraperitoneal injection of alloxan (150mg/kg) in SD rats of either sex and was divided into 5 groups of 6 animals each. Ethanolic extract of barks from Lannea coromandelica (LC 250 and 500mg/kg) and glibenclamide (10mg/kg) were orally administered once daily for 21 days in the treatment and standard group respectively. Blood glucose levels were measured on 0, 7, 14 and 21 days of oral treatment. OGTT was performed on type-2 diabetic rats and at the end of the experiment, rats were sacrificed and blood samples were collected for the measurement of total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL) and high density lipoproteins (HDL), S. creatinine ALT and AST levels. Results: The results after 21 days of oral administration of LC at doses of 250 and 500mg/kg showed a significant attenuation in blood glucose level in both the acute (p<0.001) and chronic study (p<0.001), also significantly lowered TC (p<0.001), TG (p<0.001), LDL-C (p<0.001) levels and improved HDL-C insignificantly in diabetic rats. Oral ingestion of LC very highly significantly reduced the creatinine levels (p<0.01), ALT (p<0.001) and AST (p<0.001) when compared to vehicle treated diabetic control group. These results confirmed marked improvement of the destructive effect on pancreatic islet cells induced by alloxan. Conclusion: In conclusion, our findings illustrated that the ethanolic extract of LC barks possessed glucose and lipid lowering efficacy and it is due to the protective effect on pancreas, liver and kidney from oxidative damage in alloxan-induced diabetic rats. The study provides a scientific rationale for the use of L. coromandelica in the management of diabetes and its related complications. Further studies are recommended to evaluate the precise mechanisms of action and the potential of the plant.

Keywords: Antidiabetic properties, Lannea coromandelica, antihyperlipidemic effect, alloxan induced diabetes, type-2 diabetes mellitus.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)