EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EX-VIVO PERMEABILITY STUDIES OF DIHYDROARTEMISININ-PIPERAQUINE ANTIMALARIAL IN THE PRESENCE OF FOOD COMPONENTS

Sunday O. Awofisayo*, Ekpedeme Ndem Essien and Ayodeji Akeem Agboke

ABSTRACT

The work was aimed at assessing the interactions between dihydroartemisinin-piperaquine (DP) with food components. Food components [i.e., albumin (ALB), starch (STC) and sunflower oil (SFO)] were co-loaded simultaneously with DP in excised intestinal tissues (i.e., duodenum and ileum) from New Zealand white albino male rabbits. Loaded tissues were submerged in 100 mL Tyrode solution (TS) in organ bath. DP equivalent to (100 mg/mL) of PQ was similarly loaded in duodenum and ileum as controls (CRT1 and CRT2), respectively. Sampling (5mL) was performed from organ bath at timed interval post immersion. Analysis was done using Chemstation high pressure chromatographic reverse-phase (HPLC-RP) system with Zorbact XDB C8 column and mobile phase acetonitrile: 10 mM ammonium acetate (70: 30, %v/v). The wavelength of UV detection was at 220 nm and flow rate 0.7 mL/min. PQ permeation kinetics was zero order in the presence of food components. SFO treatment revealed significant reduction in Cmax in duodenum (0.2951 versus 0.9800 μg/mL) and ileum (0.6150 versus 1.2170 μg/mL), p<0.05. ALB produced no significant difference in Peff disappearance from lumen and Peff appearance in the Tyrode solution for duodenum but higher values for ileum (p<0.05). There was higher rate for appearance (Ka) of PQ in organ bath for STC and SFO treatments in both intestinal segments, p<0.05. Similarly, the extents of permeation at 6 h (AUC6) for the treatments were lower in duodenum than the control. ALB, SFO and STC significantly affected the rate and extent of permeation of PQ across the absorptive intestinal membrane.

Keywords: Food components, Dihydroartemisinin-piperaquine, Intestinal membrane, Permeability, Antimalarial, Drug-drug interaction.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)