EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

PREDICTIVE FACTORS OF OUTCOME OF PNEUMATIC DILATION IN ACHALASIA

Meriam Sabbah*, Dalila Gargouri, Asma Ouakaa, Norsaf Bibani, Dorra Trad, Hela Elloumi and Jamel Kharrat

ABSTRACT

Introduction: Endoscopic balloon dilation (EBD) remains an essential option for treatment of achalasia. Success rate is variable depending on the study. The aim of our study was to identify predictive factors of outcome after endoscopic dilatation for primitive achalasia. Patients and Methods: Retrospective study involving patients with achalasia treated by endoscopic balloon dilatation from January 2002 to January 2016 were included. A follow up period of at least 6 months after EBD was required. Balloon dilatation was performed with Rigiflex® 30 or 35mm balloon. Criteria for failure of EBD were defined by need forrecourse toa second session of dilatation or Heller cardiomyotomy. Results: During the studied period, 120 pneumaticdilationswere performed. 100 patients whose follow-up was available for at least 6 months were included. Sex ratio was 1.12 [M /F =53/47] and average age was 42 +/- 17 years [7-88]. A recurrence of symptoms was observed in 36% of cases after the first session of endoscopic dilatation justifying a second endoscopic dilatation(in 36 cases) or surgical treatment (Heller’s cardiomyotomy) (in 6 cases). The recurrence of symptoms occurred within 5.1 +/- 3 months [1-12 months].Predictors of failure of PD were age <30 years (p =0.01), male gender (p = 0.003), vigorous achalasia (p <0.0001) and an initial PSIO<30mmHg (p=0.01). In multivariate analysis male gender (p<0,001) and vigorous achalasia (p<0,001) were independent predictors of failure of EBD. Conclusion: Independent predictive factors of poor response to endoscopic dilatation in our cohort were clinical (male gender) and manometric (vigorous achalasia). This could suggestto use another technique such as per oral endoscopic myotomy if these factors are present.

Keywords: achalasia, pneumatic dilation, predictive factors.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)