EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

NEUROPROTECTIVE AND ANTITOXIC POTENTIAL OF HYDROMETHANOLIC EXTRACT OF ALLIUM CEPA IN EXPERIMENTAL RATS

Ilochi Ogadinma*, Arthur Nwafor Chuemere, Ekwem Ikechukwu, Bassey Samuel

ABSTRACT

This research studied the neuroprotective potential of Allium cepa hydromethanolic extract on neurotoxicity due to lead acetate treatment. 30 male wistar rats were used. The animals were grouped simple randomly into 6 separate compartments. The experimental period lasted for 42 days during which the animals were subjected to various treatments. From A the control administered normal saline, B administered Allium cepa extract 100mg/kg, C administered lead acetate 500mg/kg. D, E and F co-administered 100,150 and 200 mg/kg of Allium cepa extract and lead acetate 500mg/kg. The biomarkers assayed for include protein carbonyl (PC), malondialdehyde (MDA),isoprostanes (F2IsoP) and reduced glutathione (GSH). With data significantly different at a confidence interval of 95%, there was a significant increase in GSH, but a decrease in PC, MDA and F2IsoP in the groups treated with Allium cepa extract 100mgkg and Allium cepa 150 and 200mg/kg co-administered lead 500mg/kg.lead acetate treatment alone significantly increased PC, MDA and F2IsoP but decreased GSH compared to control. Allium cepa, at the studied dose, can effectively be applied in neurotoxicity.

Keywords: Allium cepa hydromethanolic, protein carbonyl (PC).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)