EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

DIFFERENTIAL EXPRESSION OF ALPHA 2, 6 - LINKED SIALIC ACID RESIDUES ON THE CELL SURFACE OF MOUSE LYMPHOBLASTOID CELL LINES WEHI-231 AND A-20

Priyanka Banerjee*

ABSTRACT

Significant changes in sialylation are known to accompany cancer and autoimmune disease. Therefore, it is important to understand the functional role that sialic acid plays in lymphocyte development so that novel therapeutic strategies to combat these pathologies may be developed. In this study, cell surface alpha-2,6 linked sialic acid on the surface of two lymphoblastic cell lines were studied. Both both WEHI-231 and A-20 cell lines are mature B cell lines from mouse that are known to express sialic acid on their cell surfaces. This is the first study done to analyse cell surface alpha 2,6-linked sialic acid on the cell lines by flow cytometry. An investigation was done to study how cytokine IL-4 afftects the expression of cell surface alpha 2,6-linked sialic acid in these cell lines. Results clearly demonstrated that both A-20 and WEHI-231 cell lines express alpha 2,6- linked sialic acid on their cell surfaces. However, WEHI-231 cells showed a heterogeneity in their cell surface sialic acid expression, which, after stimulation with cytokine IL-4, homogeneously started expressing sialic acid on their cell surface. While a few hypotheses have been made trying to explain this characteristic change in WEHI-231 cell line, further experiments need to be carried out for a better understanding of this behaviour.

Keywords: Sialic acid, mouse lymphoblastoid cell lines.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)