EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

TARGETING ANTIOSTEOPOROTIC POTENTIAL OF ?-SITOSTEROL INAMORPHOPHALLUS PAEONIIFOLIUSUSING OVARIECTOMIZED RAT MODEL

Mrinal Sanaye* and Bhavna Bohra

ABSTRACT

Petroleum ether extract of Amorphophallus paeoniifolius (PEAP) and β-Sitosterol were evaluated for their anti-osteoporotic activity in ovariectomized rat model of osteoporosis. Thirty-six female rats (180-220 gm) were randomly divided into six groups (n=6). All groups except sham control were ovariectomized to induce osteoporosis. Treatment with PEAP (100 and 300 mg/kg, p.o) and β-sitosterol (120 mg/kg, p.o) to ovariectomized rats started from 60th day post-ovariectomy for duration of 45 days thereafter. Serum biochemical parameters (Alkaline phosphatase (ALP), calcium, inorganic phosphorous) were estimated on 1st and 45th day of treatment. Biomechanical parameters (Bone mineral density(BMD), bone weight, length and thickness, uterine weight, force at break, bone ash calcium content)and histopathology were performed at end of treatment. Elevated levels of serum ALP, calcium and phosphorous due to ovariectomy were significantly attenuated (P<0.0001, P<0.01) on treatment with PEAP and β-sitosterol. Post-ovariectomy rise in body weight was prevented in treatment groups. After administration of PEAP and β-sitosterol total femur BMD and biomechanical strength were significantly (P<0.0001) improved, confirming re-mineralization of bones. Histological results exhibited increased trabecular thickness and decrease osteoclast formation thus indicating protective activity of PEAP and β -sitosterol through promotion of bone formation and suppression of bone resorption. These results suggest that PEAP has remarkable anti-osteoporotic activity due to rich content of phytoestrogen β-sitosterol. And thus, may prove a promising candidate in treatment of post-menopausal osteoporosis.

Keywords: Amorphophallus paeoniifolius, ?-Sitosterol, Ovariectomy (OVX), Post-menopausal Osteoporosis, and Bone Mineral Density (BMD).


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 October 2018 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)