EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HIGH SENSITIVITY C-REACTIVE PROTEIN IN CHRONIC RENAL FAILURE WITH AND WITHOUT CARDIOVASCULAR COMPLICATIONS

Dr. Jawahar Subbiah, MD and *Dr. A. Ravi, MD

ABSTRACT

Introduction: Chronic renal failure patients are at greater risk of cardiovascular disease. Higher than expected cardiovascular morbidity and mortality in this population has been attributed to dyslipidaemia as well as inflammation. The causes of inflammation in chronic renal failure patients are multifactorial. Several markers were used for the detection of inflammatory reaction in patients with chronic renal disease. These markers can be used for the prediction of future cardiovascular events. Among the several parameters of inflammatory markers, serum, CRP is well known and its advantages for the detection of inflammation and its predictor ability has been evaluated in several studies. Materials and methodology: This work was done in department of Medicine at Government Rajaji Hospital, attached to the Madurai Medical College, Madurai in collaboration with departments of Nephrology and Cardiology. It is a cross sectional and analytical study. 42 newly detected CRF patients were included in the study along with 10 controls (normal individuals) and rest were cases which are newly detected CRF who satisfied the inclusion criteria were selected for the study. Patients with elevated blood urea levels, elevated serum Creatinine levels and Ultrasound abdomen showing medical renal disease were included in study. Results and Conclusion: The hs-CRP levels among CRF patients was independent of age, gender or serum creatinine levels. The hs-CRP levels was significantly elevated in CRF patients when compared to healthy controls. The hs-CRP levels were elevated significantly in those CRF patients with cardiovascular complications when compared with those without cardiovascular complications there by indicating that elevated hs-CRP is a marker of development of cardiovascular morbidity. The present study has brought out an association between elevated hs-CRP and degree of albuminuria, haemoglobin levels as well as cardiovascular morbidity. CRF patients with elevated hs-CRP should be adequately counselled regarding their proneness to develop cardiovascular complications.

Keywords: Chronic renal failure, hs-CRP, Cardiovascular diseases.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)