EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

STUDY OF ANTIMITOTIC ACTIVITY OF MURRAYA KOENIGII BY USING ALLIUM CEPA ROOT TIP ASSAY

S. G. Patil*, P. S. Patil, V. R. Patil and R. A. Ahirrao

ABSTRACT

Objective: Cancer is a dreadful disease and combating this disease is of great importance to public health. Phytochemical examination has been making rapid progress and herbal products are becoming popular as sources of plausible anticancer compounds. In the present study we have utilized the Allium cepa root tip meristem model to evaluate antimitotic activities of leaves Murraya koenigii commonly known as Curry leaves belongs to family rutaceae. Methods: Preliminary antimitotic screening was done using Allium cepa root tip assay. The herbal powder obtained from plant part-dry leaves of Murraya koenigii were extracted with aqueous solvents by maceration methods. The antimitotic activity was analysed using Allium cepa root and Methotrexate was used as a standard drugs. Result and Discussion: In Allium assay, aqueous extract of leaves of Murraya koenigii (10 mg/ml) and Methotrexate shows showed significant concentration dependant inhibitory influence against the dividing cells of Allium roots and decreased root growth and mitotic index as compared to control distilled water. The results indicated the cytotoxic potential of extract due to antimitotic effects. The effect may be attributed to the presence of flavonoids, alkaloids and phenolic compounds in Curry leaves extract. Conclusion: The present work revealed that leaves of Murraya koenigii contains some important chemical constituents extracted using aqueous as solvent that can be used further in the management of cancer treatment.

Keywords: Allium cepa, Murraya koenigii, rutaceae, maceration, flavonoids, alkaloids and phenolic compounds.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)