ASSESSMENT OF KNOWLEDGE OF MEDICAL UNDERGRADUATE STUDENTS BY ALLOTTING THEM ADR REPORTING ACTIVITY AND BY QUESTIONNAIRE METHOD

Rashmi Singla*, Dr. Rangeel Singh Raina and Dr. Dev Chaudhary

ABSTRACT

Introduction: Drug is the single active chemical entity present in a medicine that is used for diagnosis, prevention, treatment /cure of a disease. Adverse effect is any undesirable or unintended consequence of drug administration. Objectives: To assess the knowledge of students about the pharmacovigilance programme and adverse drug reactions from clinical postings acquired knowledge and ADR reports submission. Material and methods: A conclusive summary was made by assessing the performance in written questionnaire based on information provided to them about ADRs in practical lectures and based on knowledge from ADR reports submitted by 50 11nd year MBBS students who did the clinical postings and and ADR submission activity and among 50 students who did not do the ADR activity. Results: 50 students who submitted their reports, out of them 50% ADR reports were from cases related to Dermatology Deptt. and rest 50% from cases related to other depts. like Medicine, Opthalmology, Surgery, Gynecology etc The ADRs of drugs reported were mostly of steroidal creams like clobetasol cream as topical ointment, betamethsone cream, mometasone of antifungals like fluconazole ,antibiotics like cortimoxazole, cefuroxime, ofloxacin, ofantileprotic drug like clofazimine and ATT, of antiamoebics like metronidazole ,antivirals like tenofovir and eyes drops like carboxymethylcellulose. Out of 25 questions in the questionnaire, most of the students responded correctly for common 14 questions. Among 50 students who did not do the ADR exercise, 11 questions were responded differently by students. In the first question, the category of ADR to be reported was responded differently. 40 responded that only confirmed reactions should be reported, I0 students said suspected reactions and 10 said all. The kind of ADR to be reported was known and unknown by 20, serious and non serious by 10, rare and frequent by 10, rest said all should be reported.Re -challenge test definition was answered wrongly by 40 students. Most of the students said reporting ADR is not a professional obligation. Also, by whom the ADR should be reported was answered wrongly by 45 students. Mostly all the students had no knowledge of Adverse drug reaction monitoring centre(NDDTC), ADR monitoring regulatory body(CDSCO,) and national coordination centre for ADR monitoring in India(IPC, Indian pharmacovigilance centre, Gaziabad). Among rest 50 students who did the ADR reporting exercise, mostly responded correctly. The relevant medical history to be taken after the ADR was reported wrongly by most of the students. The students had varied opinion about factors which discourage them from reporting ADRs. Conclusion: The knowledge of ADR reports prepared by collecting information from clinical postings made the student aware of various aspects of ADRs and their contribution and knowledge of the pharmacovigilance program me.

Keywords: Adverse drug reaction, undergraduate students, WHO UMC causality scale.