EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

CLINICOPATHOLOGICAL STUDY OF OPPORTUNISTIC INFECTIONS IN HIV POSITIVE CHILDREN WITH SPECIAL REFERENCE TO CD4 CELL COUNT

Dr. Shantisena Mishra, Dr. Pratibha Rai, Dr. Arakhita Swain* and Dr. Saiprasanna Behera

ABSTRACT

Background: HIV in pediatric age group is a major world health problem. In India childhood, HIV amounts to around 4.4% of all cases. It is a large contributor to childhood morbidity and mortality in India. Usually the commonest cause of death in these children is opportunistic infections, which are more seen in CD4 cell count depleted children. Aims and Objectives: The study was carried out with the objectives to find out the incidence of OI in HIV positive children and its relation to CD4 cell count. Materials and Methods: Hospital based observational study conducted over on period of 2 years (Sept 2015 to Aug 2017) at pediatrics Dept. of SCB Medical College, Cuttack, India. HIV seropositive children less then 14 years of age were included in the study. Detailed clinical evaluation and lab investigations were done and they were put into WHO clinical stages. They were further classified based on CD4 count. Results: Out of total 50 cases, 28 presented in stage-III and 15 in stage-IV at first visit. Girls had higher mean CD4 count (488) than boys (340). PTB was most common OI (28%) followed by oral candidiasis. Children with OI had less CD4 cell count. Conclusion: The clinical manifestations of HIV infection in children may be similar to number of other diseases. As the WHO clinical stage and grade of malnutrition increases, CD4 count decreases thus can be a reliable marker of disease progression in HIV infected children.

Keywords: HIV, CD4 cell count, OI.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia