EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

PHENOTYPIC DETECTION OF METALLO-?-LACTAMASE AND CARBAPENEMASE AMONG IMIPENEM RESISTANT ACINETOBACTER BAUMANNII

Chaudhary Anish* and Routray Abhisek

ABSTRACT

Background: Carbapenems are the emperical and last resort of treatment used for Gram negative bacilli including Acinetobacter spp. However; an increase in carbapenem resistance among A. baumannii due to Ambler class B metallo-beta-lactamases (MBL) or class D OXA carbapenamases in recent years is of global concern. So this study was undertaken to detect antimicrobial susceptibility pattern and the presence of carbapenemase and metallo-β-lactamase among the carbapenemase resistant clinical isolates of Acinetobacter baumannii by phenotypic method.Material and Methods: A total of 130 non duplicate clinical isolates of A. baumannii from various clinical specimens were included in this study. Antimicrobial susceptibility test was carried out for all 130 isolates by Kirby Bauer disk diffusion method. Carbapenemase and metallo- β-lactamase production was tested among 76 imipenem resistant isolates of A. baumannii by modified Hodge test and combined disk test respectively. Result: In our study, resistance pattern of A. baumannii was as follows: ampicillin (91.53%), amikacin (63.07%), ceftazidime (73.07%), ciprofloxacin (73.84%), co-trimoxazole (60%), gentamicin (59.23%), imipenem (58.46%), ofloxacin (64.61%), and Piperacillin/Tazobactam(50%). Colistin and tigecycline are 93.84% and 100% sensitive respectively by disk diffusion method. Among 76 imipenem resistant isolates carbapenemase and MBL was detected in 54 (71.05%) isolates and 15 (19.73%) isolates respectively.

Keywords: Acinetobacter baumannii, Carbapenemase, Metallo-?-lactamase, Modified Hodge Test.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)