EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

POLYMORPHISMS IN APE1 AND HOGG1 DNA REPAIR GENES AND RISK OF CERVICAL CANCER IN MAHARASHTRIAN WOMEN: A HOSPITAL BASED CASE-CONTROL STUDY

Shreepad A. Joshi, Kailas D. Datkhile*, Madhavi N. Patil, Pratik P. Durgawale, Kalpita S. Korabu and Satish V. Kakade

ABSTRACT

Background: Cervical cancer is a major concern of health risk in urban and rural parts of India. Maharashtrian population is not subjected to investigate cervical cancer susceptibility in association with genetic determinants as risk factor to cause cervical cancer. This study was aimed to find out frequency of polymorphisms in DNA repair genes including Apurinic/apyrimidinic endonuclease 1 (APE1) and 8-oxoguanine DNA glycosylase 1 (OGG1) gene in patients of cervical cancer from Maharashtra, and to evaluate their association with risk of cervical cancer. Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to examine gene polymorphisms in 350 patients with cancer of cervix and 400 age and sex matched normal controls. Results: The results obtained indicated that there was no significant difference in the genotype distribution between cervical cancer patients and controls for APE1 Asp148Glu allele of codon 148 in exon 5. The result showed that genotype frequencies of hOGG1 Ser326Cys of codon 326 in exon 7 (OR=5.40; 95% CI= (3.78-7.73); p= <0.0001) were increased significantly. Conclusion: This study indicates that polymorphisms and haplotypes in hOGG1 gene appear to influence genetic susceptibility of individual to cervical cancer in Maharashtrian patients.

Keywords: Cervical cancer, Genetic polymorphism, APE1, hOGG1, PCR-RFLP.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)