EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF TRAMADOL POROUS TABLETS

Abrar*, Patnala Ramya, Tayyaba Mahtab, Sumaiyya Saleem, P. Reena Sowmya

ABSTRACT

The present research work was aimed to develop a porous tablet of tramadol using various polymers. The formulation was optimized by using various concentrations of the disintegrants and other excipients. Menthol was used as the sublimating agent. Absorption maxima was determined to be 272nm and the calibration curve was plotted using the absorbance values of various concentration of the drug. Prior to tablet making, the formulation bled was subjected to preformulation studies which were found to be within the acceptance range indicating the powder has good flow properties. Among all the eight formulations, sixth formulation (F6) having cross carmelose in the concentration of 25mg has the highest release rate where 100.26% of the drug was release within 30 mins similar to eighth formulation but sixth formulation was considered as optimized due to low sublimating agent concentration. Moreover, FT-IR spectrum obtained showed no drug-excipient incompatibility used in preparing the formulations. Therefore, the optimized formulation F6 can be employed for scale up process as the method is simple, easy and cost effective and hence can be used during large scale production.

Keywords: Porous tablet, tramadol, absorbtion maxima, preformulation studies, post formulation studies, stability.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)