THE LEVEL OF CYTOKINES IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C, DEPENDING ON THE IL-28B GENOTYPES
Adilov D. G., Aripova T. U., Ismailova A. A., Rozumbetov R. J.* and Rahimdjanov A. A.
The imbalance in the of cytokines plays a pivotal role in pathogenesis of various diseases, and chronic viral hepatitis
C is not an exception. Various cytokines, namely IL-2, IL-4, IL-6, TNF-α, IFN-α and IFN-γ, are studied in chronic
viral hepatitis C patients in accordance to their IL-28B gene polymorphisms. Obtained data showed reliable
differences between polymorphisms, thus these cytokines profiles can be used to elucidate pathology of CHVC and
help in development of novel diagnostic tools.
Keywords: Viral hepatitis C, interferons, interleukins, immunity, interleukin-28 genotypes, disease prognosis.
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