EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTICALCIC EFFECT OF AN AQUEOUS TRUNK BARK EXTRACT OF PARKIA BIGLOBOSA (JACQ. BENTH (MIMOSACEAE) ON THE SPONTANEOUS CONTRACTILE ACTIVITY OF THE ISOLATED HEART OF RAT

Kassi Yomalan, Semi Anthelme Nene Bi*, Ouga Stanislas Zahoui, Tianga Yaya Soro and Etienne Ehouan Ehilé

ABSTRACT

Objective: Parkia biglobosa (Mimosaceae) is a plant used in African traditional medicine to treat hypertension and heart disorders. Cardiac activity is underlain by particularly calcium ionic flow through the myocardial membrane. We undertook this study of the effects of an aqueous trunk bark extract of Parkia biglobosa (EAPB) on the isolated heart of rat in modified physiological solutions in order to investigate its influence on the transmembrane transport of the calcium ion which is the main activator of the heart muscle or muscle contraction. Methods: The spontaneous contractile activity of the isolated rat heart is recorded in normal physiological solution and modified physiological solutions with a Langendorff- type device. Results: An aqueous extract of Parkia biglobosa (EAPB), at concentrations between 10-14 and 10-4 mg / ml induces cardiodepressant effects (negative inotropic and chronotropic effects) dose dependent. EAPB inhibits the positive inotropic effect induced by hypercalcic, hyposodic or hypopotassic physiological media that raises the calcium level; which allows to affirm that this substance is a calcium influx inhibitor or a slow calcium channel or voltage-dependent blocker (L-type channels). This characteristic is confirmed by the accentuation of the inhibitory action of EAPB in hypocalcic physiological medium, which reduces the calcium influx, and consequently the concentration of cytosolic calcium. Conclusion: This study shows that EAPB exerts on the isolated heart an anti-calcic effect responsible for its cardiodepressor effects.

Keywords: Parkia biglobosa, isolated rat heart, calcium antagonist effect, cardiodepression.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)