EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

COMPARATIVE ASSAY OF CIPROFLOXACIN AND DOXYCYCLINE BRANDS MARKETED IN PORT HARCOURT METROPOLIS NIGERIA AGAINST Staphylococcus aureus CLINICAL ISOLATE

Hanson Ige Ogbu* and Ikhogenehata Precious Momodu

ABSTRACT

Staphylococcus aureus is among the most prominent causes of bacterial infections and because of its unique nature, it can quickly respond to new antibiotic with the development of efficient mechanisms to neutralize them. Undoubtedly, this has left fewer effective drugs to treat these often-life-threatening infections. The aim of this study was to evaluate the potency of ciprofloxacin and doxycycline brands marketed within Port Harcourt Metropolis against Staphylococcus aureus clinical isolate obtained from the Department of Microbiology University of Port Harcourt Teaching Hospital, Nigeria. The minimum inhibitory, sub inhibitory and bactericidal concentrations (MIC, MBC) of the test antibiotics were determined using standard methods. The MIC range for ciprofloxacin was 0.01953125 - 0.065104166 mg/ml, ½ × MIC, 0.009765625 - 0.032552066 mg/ml, 2 × MIC, 0.0390625 - 0.130208333 mg/ml and MBC 0.625-2.5 mg/ml. The MIC results for doxycycline ranged from 0.000325521 - 0.026041666 mg/ml, ½ × MIC 0.00016276 - 0.013020833 mg/ml, 2 × MIC 0.000651042 - 0.05208333 and MBC 0.078125 - 0.3125 mg/ml. In this study, sensitivity and effectiveness of doxycycline is higher than that of ciprofloxacin. The different brands showed variation in their sensitivity and effectiveness against the test microorganism. This disparity may be attributed to several factors including pharmacological variability between drug batches or between generic and originator drugs, incorrect drug quantity and presence of impurities, acquisition of resistance through mutations in some of their genes when they are exposed to an antibiotic. A concerted effort is required to ensure that only medicines of acceptable quality reach the end user.

Keywords: Staphylococcus aureus, minimum inhibitory concentration, minimum bactericidal concentration, ciprofloxacin, doxycycline, brands, sensitivity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)