A REVIEW ON ORGAN ON CHIP TECHNOLOGY
Swarupa Arvapalli*, P. Nandini, Md. Nabil Ahmed, Roshini Sharma and G. Jyosthna
Invitro cultured cells are showing potential advantage in assay for evaluation of Safety, efficacy, toxicity of drug candidates. These Invitro cell based assays show two major applications in drug discovery process namely; Investigation of seed molecule and Assessment of safety. They are designed to evaluate safety and toxicity in single organs, but the in vivo pharmacokinetics and pharmacodynamics of the administered drug candidates have not been considered. So an evaluating system interconnecting cell cultures is required. Accordingly, the in vitro ADME-Tox culture system known as ADME-Tox culture system has been proposed. This current review article deals with advantages, disadvantages of organs on chip and their current availability and its applications.
Keywords: Seed molecule, ADME-Tox culture system, organs on chip, Invitro cell based assay.
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