ROLE OF ASIATICOSIDE-A ON AXONAL PROTECTION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Krishnadas Madhu, Prakash T.* and Maya S.
The aim of this study is to determine the action of Asiaticoside A against acute and chronic models of experimental autoimmune encephalomyelitis in mice. In this study, we investigated Asiaticoside A against acute and chronic models of EAE in mice. Asiaticoside A treated EAE animals shown reduced progression of the disease in both models. Gene expression studies revealed that the downregulation of IL-6, TNFα, IL-17a and CCL-5 in EAE mice were depending on the extend of treatment. The treatment with asiaticoside could not reverse the downregulation of NCAM1, FOXP3 and BDNF1 levels in EAE mice. Furthermore, histopathological studies revealed that the treatment with Asiaticoside A can able to control the demyelination, infiltrations and cellular changes in brain of EAE mice. Asiaticoside A delayed the EAE progression through the inhibition of inflammatory cytokines and chemokine and not by any other mechanisms of remyelination. The anti-inflammatory effect of this compound provides an alternative therapeutic management in multiple sclerosis.
Keywords: EAE, Asiaticoside, MS, Cytokines, Multiple Sclerosis.
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