EFFECT OF ADD ON SUBLINGUAL VITAMIN D3 ON SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN PATIENTS OF HYPERTENSION ON ANTIHYPERTENSIVE TREATMENT

Sanjeeva Kumar Goud T.*, Dr. Rahul Kunkulol and Dr. Sandeep Narwane

ABSTRACT

Introduction: The aim of present study was to study effects of Sublingual Vitamin D3 on blood pressure of hypertensive patients on antihypertensive drugs. Methods: This study was Non-Randomized Clinical Trail, in which 110 Hypertensive Patients participated in the study, of which, 55 each were enrolled in Test and Control Group each. All the hypertensive patients visiting the Medicine OPD of Pravara Rural Hospital, Loni, of age between 18-60 years and either gender, willing to participate in study were included in the study. Patients on thiazide diuretics or on any other chronic medications other than antihypertensives were excluded from the study. After taking written informed consent of the study participants, the patients were assigned into Test group and Control group. The participants in the test group were given add on therapy of Sublingual vitamin D3 60,000IU every 15 days for 3 months and their blood pressure was measured. Results: There was statistically significant difference reduction in systolic blood pressure from baseline visit (134±13 mm of Hg) in comparison with Visit II, V, VI and VII (ANOVA with post hoc Tukey test). Also, there was significant reduction in systolic blood pressure when Visit II, III, and IV were compared with Visit VII. Statistically significant difference was seen on comparison of systolic blood pressure of participant in Test group with that of Control group during Visits II (P<0.05, Unpaired t test), IV, V, VI and VII (P<0.05, Mann-Whitney Test). Conclusion: Sublingual Vitamin D3 therapy causes average fall in systolic blood pressure of 15 mm of Hg. Sublingual Vitamin D3 may have an add on therapeutic role in treatment of hypertension.

Keywords: Sublingual Vitamin D3,Blood pressure,Hypertensive patients.