PREPARATION AND EVALUATION OF BCD COMPLEXED 1, 3, 7-TRIMETHYLPURINE-2, 6-DIONE, CURCUMIN ANTIOXIDANT FACIAL CREAM

Simanchal Panda*

ABSTRACT

Curcumin (diferuloyl methane), the natural yellow pigment in turmeric, is isolated from the rhizomes of the plant Curcuma longa. It constitutes about 3-4% of the composition of turmeric. Curcumin (diferuloyl methane), the natural yellow pigment in turmeric, is isolated from the rhizomes of the plant Curcuma longa. It constitutes about 3-4% of the composition of turmeric. Its role in the treatment of skin diseases and its ability to soften rough skin resulted in the prolific use of turmeric in topical creams and bath soaps in India. Turmeric is also used in home remedies in the treatment of cuts, wounds, bruises, and sprains. Its use as an anti inflammatory and antimicrobial agent has been recognized for more than a century. The importance of turmeric in medicine took a new twist when it was discovered that the dried rhizome of Curcuma longa is very rich in phenolics, whose structures have been identified as curcuminoids Phenolics are known to possess antioxidant properties. Free radical mediated damage to biological systems is recognized as the initiating agent for many diseases, such as cardiovascular diseases, cancer, and arthritis. Turmeric and its constituents show beneficial effects on these diseases and on other illnesses. Our research work is to isolate curcumin from turmeric and formulate in cream. Its anti oxidant properties help the cream to act as antiaging cream. Its evaluation test done. Curcumin is also a powerful inhibitor of the proliferation of several tumor cells, as well as an anti-inflammatory agent. It exhibits anti-carcinogenic, anti-fungal and anti-viral properties. Results: The pH of the cream base was found to be in range of 6.2-6.9 which is good for skin pH. The viscosity of was cream was in the range of 27021-27053 cps which indicates spreadibilty of cream. Acid value 5.7, saponification value 25.7. Dye test, Homogeneity, Appearance, After feel Emolliency, skin irritant test was determined and found to be satisfactory. Caffeine is an xantheine derivative mild CNS activity largly found in Cofee Cafea Arabica, tea Thea sinsensis, which is the largest consumed drink after water in the world. Here the research work is an attempt to mask the taste of bitter tasted caffeine which is an anti psychotic drug and analgesic with antihypertensive and diuretic drug. In this innovative work betacyclodextrine was taken in different molecular weight ratio with caffeine in respective parameter. Pure drug was dissolute in distilled water and compared with physical mixture, kneading mixture. The solvent taken for the drug and betacyclodextrin complexation with comparison to phase solubility study with different solvent. After solvent optimization, temperature was optimized. The dissolution study was carried out and compared. The taste masking property was analyzed by scientific committee / ethical committee. Human volunteer was tasted the pure drug which was bitter in taste. After taste masking by beta cyclodextrine complexation, it was reported by volunteer to be masked bitter taste. The caffeine was extracted by the following method. First the leaves of coffee and fruit pulp, seeds were collected from Cofee board, Koraput, Odisha, which was confirmed by Swaminathan Research centre, Jeypore, as Cofea Arabica plant. It was percolated in Faculty of Pharmacy, Kalinga University lab. Hot water overnights and filtered. The collected sample was placed in separated funnel and added chloroform. After swirling it was stood for time till two phases separated and the chloroform was collected and evaporated till caffeine was found in crystal form. The complexed drug was found to have different improved physical characteristics like bulk density, tapped density, carrs’ index, angle of repose. XRD report shown the complexed drug to have more stabilized than pure drug. As the complex shows fuse peaks at low intensities indicating more stable and soluble, compare to the pure drug having intensed peaks showng crystalline nature which indicates its non soluble nature. Micromeritics study of pure drug. The complexed caffeine and curcumin formulated in cream and parameters were evaluated.

Keywords: BCD, 1, 3, 7-Trimethylpurine-2, 6-Dione, Curcumin, XRD, facial cream.