SYNTHESIS OF NEWLY SUBSTITUTED PYRAZOLE DERIVATIVE AND THEIR ANTIINFLAMMATORY ACTIVITY
*Dr. Indu Singh
A series of novel pyrazole derivatives have been synthesized by the reaction of substituted chalcones with
phenylhydrazine. The starting materials were prepared by reaction of acetophenone with substituted aldehydes in
presence of sodium hydroxide. The structure of newly synthesized compounds has been characterized by using
elemental analysis and IR and 1HNMR spectral analysis. The melting points of synthesized compounds were
determined in open capillaries with the help of thermonic melting point apparatus and the homogeneity of newly
synthesized compounds was checked by TLC. The synthesized compounds have been evaluated to determine their
anti-inflammatory activity. The anti-inflammatory activity of synthesized compounds was compared by
phenylbutazone. In this series compound 2j showed better anti-inflammatory activity than standard drug.
Keywords: Pyrazole, anti-inflammatory activity, phenylbutazone.
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