EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

SYNTHESIS OF NEWLY SUBSTITUTED PYRAZOLE DERIVATIVE AND THEIR ANTIINFLAMMATORY ACTIVITY

*Dr. Indu Singh

ABSTRACT

A series of novel pyrazole derivatives have been synthesized by the reaction of substituted chalcones with phenylhydrazine. The starting materials were prepared by reaction of acetophenone with substituted aldehydes in presence of sodium hydroxide. The structure of newly synthesized compounds has been characterized by using elemental analysis and IR and 1HNMR spectral analysis. The melting points of synthesized compounds were determined in open capillaries with the help of thermonic melting point apparatus and the homogeneity of newly synthesized compounds was checked by TLC. The synthesized compounds have been evaluated to determine their anti-inflammatory activity. The anti-inflammatory activity of synthesized compounds was compared by phenylbutazone. In this series compound 2j showed better anti-inflammatory activity than standard drug.

Keywords: Pyrazole, anti-inflammatory activity, phenylbutazone.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)