EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

COMPARATIVE STUDY OF CERTAIN COMMERCIALLY AVAILABLE BRANDS OF PARACETAMOL TABLETS IN SANA'A CITY, YEMEN

Mahmoud Mahyoob Alburyhi, Abdalwali A. Saif, Maged Alwan Noman*, Moktar Algorafy

ABSTRACT

Evaluation of the physiochemical properties of the pharmaceutical products can ensure their quality as well as bioavailability and impart optimum therapeutic activity. In general, drugs must be marketed as safe and therapeutically active formulations whose performance is consistent and predictable. Acetaminophen is a non-steroidal anti-inflammatory drug frequently prescribed for relief of pain and fever. The present study was conducted to access the quality control parameters of nine different brands marketed in Yemen and compare weight variation, hardness, friability, and assessment of state content as prescribed in official monograph using acetaminophen standards. For weight variation, all the nine brands of paracetamol tested conformed to the BP weight variation test. For hardness the result show that all brands complied with the standard BB/USP specification for tablet hardness 4-10 kg/cm, except two brands fail, Paramol and Ramol. All brands showed impressive friability values and the products of multinational companies comparatively exhibited the highest values, all the brands of paracetamol tablets had passed friability specification and values of <1% which considered to be highly satisfactory according to BP/USP. All the nine brands of paracetamol shown their disintegration within 15 minutes as specified by BP/USP. For drug content, high-performance liquid chromatography was used to determine Paracetamol content, and all brands showed good chemical analysis profile which would further help in achieving optimum bioavailability and in fulfilling the patient demands.

Keywords: Paracetamol, hardness, friability, disintegration, market.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 October 2018 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)