EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ULCER HEALING EFFECT OF ETHANOLIC EXTRACT OF UNRIPE MUSA PARADISIACA ON ASPIRIN INDUCED GASTRIC ULCERATION IN ADULT WISTAR RATS

Nweke Elizabeth Obioma, Opara Julia Kelechi*, Nweke Tochukwu Miracle, Ewa Ogbonnaya, Ndibe Offor Sunday

ABSTRACT

This study investigated the ulcer healing potential of unripe Musa paradisiaca fruit on aspirin induced gastric ulcer. Twenty five (25) adult wistar rats were divided into five groups (A, B, C, D and E) of five rats each. Group A was administered with 2ml/kg distilled water orally (normal control), Group B was administered with 300mg/kg b.w aspirin orally (negative control) Groups C-E were administered with 300mg/kg aspirin orally prior to treatment with 100, 500 and 1000mg/kg b.w orally respectively. The animals were sacrificed by cervical dislocation and ulcer index was determined on harvested stomach tissue. Oral administration of aspirin caused a significantly high ulcer index (1.53±0.46). However, treatment with extract of Musa paradisiaca fruit significantly reduced the ulcer index in a dose dependent manner in which 0.44±0.02 was recorded on 1000mg/kg of the extract. The observation was in concordance with that of the percentage ulcer inhibitory result which was also found to be dose dependent with 71.24% inhibition recorded on administration of 1000mg/kg of the extract. From the findings, it can be deduced that unripe Musa paradisiaca fruit have ulcer healing potential and should be recommended as an ideal diet for individuals on high risk category for gastric ulcer resulting from NSAID treatment.

Keywords: Musa paradisiaca, Ulcer, Stomach, Aspirin.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 October 2018 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR OCTOBER ISSUE PUBLISHED

    OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)