EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

DENGUE FEVER INFECTION EVALUATION OF ANTI-DENGUE IGM OR IGG USING NUMEROUS RAPID DIAGNOSTIC TESTS (RDTS)

Won-Shik Kim, Yong-Gyoo Lee, Man Kyu Huh and Yong Lim*

ABSTRACT

Dengue fever (DV) is a mosquito-borne tropical disease caused by one of four dengue viruses. It is necessary to test the commercial rapid diagnostic kits for DV infection. In this study, we evaluated the accuracy and precision of DV relative to the manufacturer’s specifications at General Hospital Kulala Lumpur, KL, Malaysia. Three commercially available dengue rapid diagnostic tests (RDT) kits were evaluated. We used Asan Easy Test, BIOLINE Dengue Duo, and PanBio as the RDT in the study. Specificity of Asan Easy Test was 100.0% (75/75) for IgM and its sensitivity was 64.6% (73/113). The detection of IgG was same trend. Specificity of Asan EasyTest was 100.0% (75/75) for IgG and its sensitivity was 31.6% (18/57). Specificity of SD BioLine was 100.0% (75/75) for IgM and its sensitivity was 53.7% (50/113). Specificity of SD BioLine was 100.0% (75/75) for IgG and its sensitivity was 21.0% (12/57). Specificity of PanBio was 100.0% (75/75) for IgM and its sensitivity was 41.5% (47/113). Specificity of PanBio was 100.0% (75/75) for IgG and its sensitivity was 22.9% (13/57). Asan EasyTest had greater overall sensitivity than SD BioLine and PanBio.

Keywords: Asan EasyTest, Dengue fever (DV), dengue rapid diagnostic tests (RDT), IgG, IgM.

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