EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECTS OF STRONTIUM CHLORIDE HEXAHYDRATE IN CAENORHABDITIS ELEGANS INDIVIDUALS AS A MODEL FOR SKIN AGING

*Rukiye Güner, Sibel Berksoy Hayta, Necati Özp?nar, Melih Akyol, Mustafa Tosun and 6Sedat Özçelik

ABSTRACT

Backround: Collagen destruction is related to the presence of matrix metalloproteinase (MMP) that are released by epidermal keratinocytes and dermal fibroblasts and the MMP-1 expression stimulated by ultraviolet radiation is provided by the protein kinase C-dependent (PKC)-dependent activation of transient receptor potential vanilloid 1 (TRPV-1) in human keratinocytes and subsequent calcium (Ca2+) transition. Strontium is a an alkaline-earth metal with chemical and biological behaviors similar to calcium. Objective: To investigate whether strontium chloride hexahydrate has anti-aging effects on Caenorhabditis elegans. Materials and Methods: After treatment with strontium solutions, the lifespan, physical development and pharynx pumping numbers of C.elegans were determined and compared with the control group. Results: An increase in strontium-exposed C.elegans depending on the dosage increase in their lifespans was specified. İt was determined that physical development in strontium-exposed C. elegans decreased depending on the dosage. It was specified that pharynx pumping count per minute decreased depending on the strontium dosage. Conclusion: Strontium chloride hexahydrate slowed down the developmental process of C.elegans and extended their lifespans. Strontium chloride hexahydrate may have a positive effect on skin aging in humans with similar mechanisms.

Keywords: Strontium, anti-aging, calcium, Caenorhabditis elegans, lifespan, skin aging.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)