EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

SCREENING OF PHARMACOLOGICAL EFFECT OF METHANOL EXTRACT OF LEAVES OF LIBYAN CAPPARIS SPINOSA SUBSP ORIENTALIS (DUH.) JAFRI ON VITAL ISOLATED ORGANS

Salwa I. Eltawaty*, Mohamed-Elfatih A. Omare, Aisha Z. Almagboul, Amna E. H. Mohammad, Imad Eldin Mohamed Taj Eldin and Amjad M. A. A. Hamza

ABSTRACT

The present study was undertaken to evaluate the effect of the methanol extract of leaves of Capparis spinosa on vital isolated organs (Rabbit aorta strip, Rabbit jejunum, Rat uterus and Frog rectus abdominus muscle) with use of standard methods. Results: The results revealed that methanol extract of leaves of Capparis spinosa has weak cholinergic effect on isolated rabbit jejunum which completely antagonized with 10ng/ml Atropine. Also the result showed that the extract has a potentiating effect to the reference Nor-epinephrine at low doses up 400μg/ml which completely reversed to Nor-epinephrine antagonizing effect at high doses of ≥ 1600μg/ml. Conclusion: Methanol extract of leaves of Capparis spinosa has weak cholinergic effect on isolated rabbit smooth muscle, Norepinephrine potentiating effect at low doses and antagonizing effect on Nor-epinephrine at higher doses on isolated rabbit Aorta. The plant has no effect on tested isolated uterus and frog abdominus muscle.

Keywords: Capparis spinosa, Pharmacological effects, Isolated vital organs.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)