EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

CURCUMIN AMELIORATES THE HAZARD EFFECT OF PRENATAL BETAMETHASONE ADMINISTRATION ON THE FETAL ADRENAL GLAND OF ALBINO RATS

*Gamal M. Badawy

ABSTRACT

The present study aimed to investigate the possible adverse effects of maternally injected betamethasone on the developing adrenal gland of the albino rat (Rattus norvegicus) fetuses. Another aim was to ameliorate these adverse effects using crude water extract of curcumin. The experimental pregnant rats were injected with betamethasone alone, curcumin alone, betamethasone followed by an oral injection of curcumin while the control ones were injected with distilled water. Injection started from gestation day (GD) 11 and ended at DG 16. For the sake of eliminating differences owing to the time factor, the experiments were terminated at the 20th day of pregnancy for all groups. The released fetuses were dissected and the adrenal glands were taken out for investigation. Three integrated approaches namely, histological, immuno-histochemical and ultrastructural were adopted. Betamethasone prenatally administration caused massive destructive changes within the two components of the adrenal gland i.e. the cortex with its three zones and the medulla at all the three adopted levels. The study provided clear evidences for the ameliorative role of curcumin against the hazard effect of the maternally administered betamethasone upon the developing adrenal gland.

Keywords: Curcumin, Betamethasone, Adrenal gland, Rat fetuses.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)