EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HEPATOTHERAPEUTIC POTENTIALS OF SIDA CORYMBOSA (WIRE WEED) ETHANOLIC LEAF EXTRACT ON CARBON TETRACHLORIDE (CCL4)-INDUCED ACUTE HEPATOTOXICITY ON MALE ALBINO WISTAR RATS

Charles Chijioke Dike*, Friday Chuwuemeka Ezeonu, Hugh Clifford Chima Maduka, Ezeokafor Emmanuel Nonso and Oguazu Chinenye Enoch

ABSTRACT

Aim: This work aimed at evaluating the hepatotherapeutic potentials of Sida corymbosa ethanolic leaf extract against carbon tetrachloride (CCL4)-induced hepatotoxicity on male Albino Wistar rats. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphate (ALP) were determined spectrophotometrically. Body and liver weights were measured using electronic weighing balance, while water consumption was measured using calibrated water bottle. Histopathological examination was carried out using hematoxyline and eosine (H and E) staining technique. Results were analyzed using ANOVA, using SPSS statistical software (version 21). The liver function (Serum AST, ALT, and ALP) assays carried out revealed significant decrease (P<0.05) in the levels of serum AST, ALT and ALP in groups of rats administered 5000, 3000 and 1000 mg/kgbw of the extract after inducing hepatotoxicity using CCL4 against groups induced hepatotoxicity without given any treatment from seven days to twenty eight days which had. These are suggesting that the treated rats with the extract may be recovering from the hepatic injury. The above changes were greatest in those administered the extract at 5000 mg/kgbw for 28 days. This suggests dose and time dependent effect. The treatment also showed positive effects on body weights and water consumption of the treated rats. The above findings were confirmed by the histological examination carried out. Sida corymbosa ethanolic leaf extract may therefore has some therapeutic effects on the livers of male Albino Wistar rats damaged by CCL4 toxicity.

Keywords: Hepatic injury, Liver functions, sida extract.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)