A CONCISE REVIEW ON PYRAZOLINE DERIVATIVE FOR DIABETES MELLITUS
E. Ajila*, R. Aniz K. Roy, S. M. Sandhya, A. S. William Arputha Sundar, M. S. Padmaja Devi1 and Lakshmi Gopal R.
The N-phenyl Pyrazoline ring with aryl substitution at third and fifth position exhibits better biological activities.
The most common procedure for the synthesis of 2-pyrazolines is the reaction of an aliphatic or aromatic hydrazine
with α,β-unsaturated carbonyl compounds. 2-Pyrazolines synthesized by the cycloaddition of diazomethane with
substituted chalcones. 2-Pyrazolines can also be prepared by the condensation of chalcone dibromide with
hydrazine. A number of diarylidene cycloalkanones on reaction with hydrazine hydrate produce pyrazolines.
Dipolar cyclo addition of nitrilimines to dimethyl fumarate, fumaro nitrile and the N-aryl maleimides yields the
corresponding pyrazolines. Reaction of Et 2-(phenylazo)-3-oxobutanoates with nicotinic acid hydrazide using
glacial acetic acid gives pyrazoline derivatives. Diabetes mellitus is a common and very prevalent disease affecting
the citizens of both developed and developing countries. It is estimated that 25% of the world population is affected
by this disease. Most patients can be classified clinically as having either Type 1 diabetes mellitus. Historically,
different substituted pyrazoles were known for their hypoglycemic activity, but in a search for novel structural
classes of drugs inhibiting the activity of the ATP-K + channel of the beta cell pancreatic membrane, inducing the
production of insulin we turned our attention to substituted pyrazoline derivatives.
Keywords: Pyrazoline, Phenyl hydrazine, Acetophenone, Aldehyde, Diabetes mellitus.
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