EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

A CONCISE REVIEW ON PYRAZOLINE DERIVATIVE FOR DIABETES MELLITUS

E. Ajila*, R. Aniz K. Roy, S. M. Sandhya, A. S. William Arputha Sundar, M. S. Padmaja Devi1 and Lakshmi Gopal R.

ABSTRACT

The N-phenyl Pyrazoline ring with aryl substitution at third and fifth position exhibits better biological activities. The most common procedure for the synthesis of 2-pyrazolines is the reaction of an aliphatic or aromatic hydrazine with α,β-unsaturated carbonyl compounds. 2-Pyrazolines synthesized by the cycloaddition of diazomethane with substituted chalcones. 2-Pyrazolines can also be prepared by the condensation of chalcone dibromide with hydrazine. A number of diarylidene cycloalkanones on reaction with hydrazine hydrate produce pyrazolines. Dipolar cyclo addition of nitrilimines to dimethyl fumarate, fumaro nitrile and the N-aryl maleimides yields the corresponding pyrazolines. Reaction of Et 2-(phenylazo)-3-oxobutanoates with nicotinic acid hydrazide using glacial acetic acid gives pyrazoline derivatives. Diabetes mellitus is a common and very prevalent disease affecting the citizens of both developed and developing countries. It is estimated that 25% of the world population is affected by this disease. Most patients can be classified clinically as having either Type 1 diabetes mellitus. Historically, different substituted pyrazoles were known for their hypoglycemic activity, but in a search for novel structural classes of drugs inhibiting the activity of the ATP-K + channel of the beta cell pancreatic membrane, inducing the production of insulin we turned our attention to substituted pyrazoline derivatives.

Keywords: Pyrazoline, Phenyl hydrazine, Acetophenone, Aldehyde, Diabetes mellitus.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)