EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HEMIDESMUS INDICUS L.: EVALUATION OF SEDATIVE & HYPNOTIC EFFECT IN THE ELEVATED PLUS-MAZE APPARATUS

Javed Khan Pathan*, Girendra Gautam and Arun Kumar Gupta

ABSTRACT

This is the preliminary study of Hemidesmus indicus L. for sedative and hypnotic activity. The plant is used as folk medicine. In present work sedative & hypnotic like properties were evaluated for ethanolic & aqueous extract of H. indicus L. Stem & Leaves. Thiopental Sodium has been used as an index for the hypnotic effect. Loss of the righting reflex was used to determine start of sleep. The sleep latency and sleeping time were evaluated in the present study. The results showed that extracts could obviously shortens the sleep latency and prolongs the sleeping time of mice produced by thiopental sodium (60 mg/kg, i.p.). Stem & Leaves extracts were produced significant sedative & hypnotic effect in elevated plus-maze. The dose-effect relationship is remarkable. Aim of Study: The goal is to use the evidentiary strengths thatboth systems (Ayurvedicand Westernparadigms) of thought bring to the table, taking care nottoevaluateonesystemusingthelensoftheother system, but to come to a better understanding of anantamulandwhatithastooffer. Presently increasing demand of herbal products acquired in global markets, as well as medicinal plants collected for personal consume are a known modern tendency. In the present study, ethnomedicinal use of H. indicus L.stem & leavesas sedative and hypnotic has been studied & evaluated.

Keywords: Hemidesmus indicus, H. indicus, sedative & hypnotic, thiopental sodium, sleepingtime.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)