EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF SUPERPOROUS HYDROGEL TABLETS OF RABEPRAZOLE SODIUM AS A GASTRORETENTIVE SYSTEM

Parthiban K. G.1, Ragunathan Muthuswamy*2 and Dilna Deepan3

ABSTRACT

The present study intends to carry out the formulation and evaluation of gastro retentive drug delivery system based on superporous hydrogel tablet using rabeprazole sodium. Rabeprazole sodium belongs to the class of antisecretory compounds which suppress gastric acid secretion by the specific inhibition of the H+/K+-ATPase enzyme. The drug rabeprazole sodium has low bioavailability of 52%, superporous hydrogel have fast swelling property, minimized rupturing, increased gastric residence time and also increased solubility, so to increase bioavailability and also to increase gastric residence time it is designed as a gastro retentive superporous hydrogel system. Superporous hydrogel swells rapidly in the stomach. The prepared superporous hydrogel may withstand various types of stress like compression, mechanical strength, stability in acidic condition of stomach and also gives effective pore size larger than 10 micrometre. Gastro retentive superporous hydrogel are generally characterized by their size, morphology, Scanning electron microscopy (SEM), porosity measurement, determination of void fraction, water retention capacity, and determination of drug content. Advantage of converting into superporous hydrogel tablet is to achieve improved therapeutic advantage, such as ease of dosing administration, patient compliance and flexibility in formulation.

Keywords: Gastroretentive drug delivery system, Superporous hydrogel, Swelling, Gastric residence time.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)