EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF FAMOTIDINE USING SUPERDISINTEGRANTS

V. Jhansi Priya Marabathuni*, G. Nireesha, I. Adilakshmi, J. Krishnaveni, K. Anjaneya Gupta, K. Venkata Lakshmi and Ch. M. M. Prasada Rao

ABSTRACT

The objective of the present investigation was to prepare oro dispersible tablets of Famotidine, because of their convenience in administration and suitability for patients having dysphagia. Tablets were prepared by direct compression using sodium starch glycolate and croscarmellose sodium and crospovidone as superdisintegrants. Microcrystalline cellulose pH-102 was used as diluent and mannitol, sodium saccharine to enhance the organoleptic properties of tablets. The tablets were evaluated for weight variation, hardness, friability, assay, invitro disintegration time, in-vitro dissolution study. Hardness and friability data indicated good mechanical strength of tablets. The results of in-vitro disintegration time indicated that the tablets dispersed rapidly in mouth within 60 seconds. It was concluded that superdisintegrants addition technique is a useful method for preparing oro dispersible tablets by direct compression method.

Keywords: Oro dispersible tablets, Famotidine, Superdisintegrant, Sodium starch glycolate, Croscarmellose sodium, Crospovidone.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)