EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HYPERACUTE HYDRALAZINE INDUCED LIVER INJURY

Prithvi Ganesh Mavuri, MD*, Kyle Mahoney and Joseph H. Schafer

ABSTRACT

Drug induced liver injury secondary to Hydralazine use, although rare, has been documented. Of those cases described, the time course for liver injury is either a short (2-6 weeks) or long (2-12 months) latency period after starting the drug. We report a case of a patient who, after being treated with Hydralazine, developed an acute liver injury on a timeline that wasn’t previously described. A 64-year-old African American female with a past medical history remarkable for coronary artery disease and hypertension presented to our hospital complaining of chest pain. She was admitted for management of NSTEMI. During the course of her stay, the patient was noted to have hypertensive urgency and antihypertensive regimen including Hydralazine was started. After receiving multiple doses of hydralazine, the liver transaminases began to trend upward, peaking within 24 hours of starting the drug. Establishing causality of liver injury to hydralazine was done by using the RUCAM scoring system. By doing so, this case however presents the possibility of a “hyperacuteâ€Â timeline for Hydralazine induced liver damage, in this case, within 24 hours of starting hydralazine.

Keywords: Hydralazine, drug-induced, liver injury, DILI, autoimmune, hepatitis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)