EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

INCIDENCE OF ANTIVIRAL THERAPY IN AMELIORATING HEPATITIS C ASSOCIATED COMORBIDITIES IN TAIWAN: A 7 YEAR FOLLOW UP NATIONWIDE POPULATION-BASED STUDY

Yueh-Chin Chung, Ph. D., Shu-Fen Li, Ph. D., Mei-Wen Lee, Ph. D., Chien-Wei Wu, MBA., Horng-Mo Lee, Ph. D., Chin-Chih Ho, Ph. D. and Chin-Tun Hung, Ph. D.*

ABSTRACT

Objectives: Hepatic C Virus (HCV) infection is associated with development of type 2 diabetes (T2D). This population-based study was designed to assess whether anti-viral therapy following HCV-infected hepatitis may reduce the incidence rates of T2D and hazard ratios for associated cormobidities. Methods: A total of 13,025 subjects were retrieved from the NHIRD cohort from 2000 to 2003. Among them, 2641 (20%) were diagnosed with HCV-infected hepatitis, and 10,564 HCV negative subjects served as control group. Among the 2,641 HCV-infected subjects, 139 (5.3%) subjects received IFN/RBV therapy.The other 2,502 hepatitis C patients not receiving IFN/RBV therapy served as comparison group. Results: Among the 10,564 HCV sero-negative control subjects, 920 subjects (8.7%) developed T2D in 7 years. On the other hand, there were 444 (16.8%) HCV-infected subjects developed T2D in 7 years. HCV-hepatitis patients were more likely to develop T2D (hazard ratio 2.097, 95% CI 1.872–2.348; p <0.001). Among the 2502 HCV patients not receiving IBT therapy, 434 patients (17.3%) developed T2D in 7 years. In contrast, only 10 (7.2%) in 139 HCV-infected subjects who received IBT therapy developed T2D in 7 years. The adjusted hazard ratio was 0.341 (95% CI 0.182–0.639; p<0.001).The hepatitis C patients have a higher incidence of T2D, hepatic steatosis, cardiovascular disorders and hepatocellular carcinoma (HCC). After interferon-base therapy intervention T2D significantly reduce its incidence. Conclusions: Our data suggest that HCV infection was associated with increased risk of T2D, and anti-viral therapy may be reduce the incidence of T2D.

Keywords: Hepatitis C virus (HCV), Type 2 diabetes (T2D), Epidemiology, Incidence, Hazard ratios.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)