TESTICULAR TOXICITY INDUCED BY EXOGENOUS BETAMETHASONE AND THE AMELIORATIVE ROLE OF CURCUMIN IN ADULT AND FETAL STAGES OF ALBINO RATS
*Gamal M. Badawy
Betamethasone is one of the most usual drugs in both human and animal medication. This study dealt with the
testicular toxicity induced by exogenous betamethasone in the adult and fetal stages of the albino rats (Rattus
norvegicus) and its amelioration by curcumin. It involved four parameters, namely, histopathological,
histomorphometric, immune-histochemical and biochemical. The results showed that 0.1 mg/kg body weight of
betamethasone injected daily to the adult males for 6 days caused destructive changes in the histological
architecture and significant decrease in testosterone and luteinizing hormones (LH) concentrations. Male rat fetuses
maternally injected with the same dose for the same period (from day 14 to day 19 of pregnancy which constitute
the critical days of prenatal reproductive development) also displayed testicular toxicity. In conclusion, the
outcome of the present results raise concerns about the use of betamethasone in human therapy. While the results
revealed the evident testicular toxicity of betamethasone, it proved that curcumin at a dose of 15.75 mg/kg body
weight is a potential ameliorative agent against this toxicity during both adult and fetal stages.
Keywords: Betamethasone, Curcumin, Testicular toxicity, Histopathology, Testosterone, Luteinizing hormone, Fetuses.
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