EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

TESTICULAR TOXICITY INDUCED BY EXOGENOUS BETAMETHASONE AND THE AMELIORATIVE ROLE OF CURCUMIN IN ADULT AND FETAL STAGES OF ALBINO RATS

*Gamal M. Badawy

ABSTRACT

Betamethasone is one of the most usual drugs in both human and animal medication. This study dealt with the testicular toxicity induced by exogenous betamethasone in the adult and fetal stages of the albino rats (Rattus norvegicus) and its amelioration by curcumin. It involved four parameters, namely, histopathological, histomorphometric, immune-histochemical and biochemical. The results showed that 0.1 mg/kg body weight of betamethasone injected daily to the adult males for 6 days caused destructive changes in the histological architecture and significant decrease in testosterone and luteinizing hormones (LH) concentrations. Male rat fetuses maternally injected with the same dose for the same period (from day 14 to day 19 of pregnancy which constitute the critical days of prenatal reproductive development) also displayed testicular toxicity. In conclusion, the outcome of the present results raise concerns about the use of betamethasone in human therapy. While the results revealed the evident testicular toxicity of betamethasone, it proved that curcumin at a dose of 15.75 mg/kg body weight is a potential ameliorative agent against this toxicity during both adult and fetal stages.

Keywords: Betamethasone, Curcumin, Testicular toxicity, Histopathology, Testosterone, Luteinizing hormone, Fetuses.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)