EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

DETERMINATION OF EFFICACY AND MECHANISM OF ACTION OF ANTIOXIDANTS COMPONENTS FROM BLACK CUMMINS (NIGELLA SATIVA) AND SWALLOW ROOT (DECALEPIS HAMILTONII) USING IN VITRO BIOCHEMICAL AND CELL CULTURE ASSAY MODEL SYSTEMS

*Vulli Venkata Rao, Vempati Poornodai, Nancy Bonareri Mitaki and Suberu Safiu Adewale

ABSTRACT

Binding of phenolics including antioxidants to plasma proteins is an important pharmacological parameter, since it frequently affects the distribution and elimination of these compounds, which dictates the duration and intensity of physiological action. This study was conducted to know the efficacy and mechanism of action of antioxidant components from black cumis (Nigella sativa) and swallow root(Decalepis hamiltonii) using In vitro biochemical cell culture assay model. Determination of binding ability of BCAE and SRAE indicated that all phenolic acids have the ability to bind to protein and DNA at varied levels. Tannic acid followed gentisic and gallic acid appear to bind strongly to both - a carrier protein– Human Serum Albumin and DNA. Binding of these components to target protein is implicated in enhancement of bioavailability and hence bioactivity. Interaction of phenolic acids thus is an important tool to predict the antioxidant potency in vivo.

Keywords: Nigella sativa, Decalepis hamiltonii.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)