EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

GC/MS ANALYSIS PRODUCTS AND THEIR RELATION WITH THE ANTIMICROBIAL ACTIVITY OF LEAVES AND BARK OF CAPPARIS SPINOSA SUBSP ORIENTALIS (DUH.) JAFRI

Salwa Ibraheim El-Tawaty*, Mohamed-Elfatih Ahmed Omare, Aisha Zoheir Almagboul and Sanaa Osman Yagoub

ABSTRACT

This study aimed to analyze the phytochemical constituents and investigate the antimicrobial activity of Capparis spinose crude bark and leaves extracts against different microorganisms. Methods: Gas Chromatography/ Mass Spectra (GC/MS), Disc diffusion method and dilution agar plate assays were used for analysis and to evaluate the antimicrobial activities and minimum inhibitory concentrations. Results: Extracts of Capparis spinosa leaves and bark from different solvents showed variable in – vitro activity against tested standard strains and clinical isolates with highly significant differences; P˂ 0.01. The highest activities were shown from chloroform bark extract and methanol leaves extract with equal minimum inhibitory concentration of 100mg/ml against standard Staphylococcus aureus ATCC 25923 and clinical methicillin resistant Staphylococcus aureus. GC/MS analysis revealed 33 and 25 compounds from extracts of the plant leaves and bark, respectively and the study suggested that the antimicrobial activity shown is referred to these phytochemical constituents such as flavonoids, tannins, steroids and triterpines. Conclusion: Capparis spinose subsp orientalis (Duh. Jafri leaves and bark extracts composed of flavonoids, tannins, steroids and triterpines which have the ability to reduce surface colonization and to control the penicillin binding proteins of Staphylococcus aureus, and this make the plant have a pronouncing anti Staphylococcus aureus especially with the limited treatment choices presented for treatment of infections caused by this bacterium.

Keywords: Capparis spinosa, GC/MS analysis, phytochemical constituents, Staphylococcus aureus.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)