EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EVALUATION OF ANTI-OBESITY AND DIURETIC EFFECTS OF AQUEOUS EXTRACT OF TETRAPLEURA TETRAPTERA TAUB. STEM BARK ON HIGH FAT DIET-INDUCED OBESE RATS

Olivette Laure Matafack Dongmo, Evariste Leonce Azabadji Ashu, Herve Tchoumbou Tadjoua, Nadine Joissy Epoh, Sylvain Nguedia Njina, Leon Azefack Tapondjou and Phelix Bruno Telefo*

ABSTRACT

Background: Tetrapleura tetrapteura Taub. is a medicinal plant belonging to family of Fabaceae and native to West Africa. Its used in the management of hypertension, diabetes mellitus, and hyperlipidemia. In the present study, the anti-obesity and diuretic effect of the aqueous extract of Tetrapleura tetraptera stem bark was investigated in high fat diet induce obese rats. Methods: Obesity was induced in rats by using high fat diet for 16 weeks. After induction, animals were treated during 28 days with plant extract at the doses of 100, 200, 400 mg/kg and Orlistat at 5mg/kg. The effect of the treatment was evaluated on food intake, body weight and Lee index. The organ and fat weights were taken. The urinary volume was noted and the urinary electrolytes (K+, Na+ and Cl-) level as well as biochemical parameters and atherogenic index were evaluated at the end of the treatment. Results: The oral administration of extract leads to a significant decrease in body weight, fat weight and food intake as well as the serum levels of triglycerides, total cholesterol, LDL-cholesterol, atherogenic and Lee index in the obese animals. Those treated with the doses of 200 and 400 mg/kg of body weight showed significant decreased of these parameters compared to orlistat (standard drug). The evaluation of diuretic effect showed that extract significantly increased the urine output and the urinary electrolytes level in obese animals. Conclusion: The aqueous extract of Tetrapleura tetraptera stem bark has a protective effect against weight gain, triglycerides, cholesterol and electrolytes retention on high fat diet induce obese rat.

Keywords: Tetrapleura tetraptera, obesity, Lee index, electrolytes retention, high-fat diet.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 January 2019 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR JANUARY ISSUE PUBLISHED

    JANUARY 2019 Issue has been successfully launched on 1 January 2019

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)