EVALUATION OF ANTI-OBESITY AND DIURETIC EFFECTS OF AQUEOUS EXTRACT OF TETRAPLEURA TETRAPTERA TAUB. STEM BARK ON HIGH FAT DIET-INDUCED OBESE RATS
Olivette Laure Matafack Dongmo, Evariste Leonce Azabadji Ashu, Herve Tchoumbou Tadjoua, Nadine Joissy Epoh, Sylvain Nguedia Njina, Leon Azefack Tapondjou and Phelix Bruno Telefo*
Background: Tetrapleura tetrapteura Taub. is a medicinal plant belonging to family of Fabaceae and native to West Africa. Its used in the management of hypertension, diabetes mellitus, and hyperlipidemia. In the present study, the anti-obesity and diuretic effect of the aqueous extract of Tetrapleura tetraptera stem bark was investigated in high fat diet induce obese rats. Methods: Obesity was induced in rats by using high fat diet for 16 weeks. After induction, animals were treated during 28 days with plant extract at the doses of 100, 200, 400 mg/kg and Orlistat at 5mg/kg. The effect of the treatment was evaluated on food intake, body weight and Lee index. The organ and fat weights were taken. The urinary volume was noted and the urinary electrolytes (K+, Na+ and Cl-) level as well as biochemical parameters and atherogenic index were evaluated at the end of the treatment. Results: The oral administration of extract leads to a significant decrease in body weight, fat weight and food intake as well as the serum levels of triglycerides, total cholesterol, LDL-cholesterol, atherogenic and Lee index in the obese animals. Those treated with the doses of 200 and 400 mg/kg of body weight showed significant decreased of these parameters compared to orlistat (standard drug). The evaluation of diuretic effect showed that extract significantly increased the urine output and the urinary electrolytes level in obese animals. Conclusion: The aqueous extract of Tetrapleura tetraptera stem bark has a protective effect against weight gain, triglycerides, cholesterol and electrolytes retention on high fat diet induce obese rat.
Keywords: Tetrapleura tetraptera, obesity, Lee index, electrolytes retention, high-fat diet.
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