EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

FORMULATION AND EVALUATION OF MINOCYCLINE HYDROCHLORIDE EXTENDED RELEASE MATRIX TABLETS

Arigela Bharathi*, Vaida Aswini Priya, Nadikatla Anusha, Sali Roja, Garikipati Priyanka

ABSTRACT

The present study was aimed to formulate and evaluate minocycline hydrochloride (MIN) extended release matrix tablets, using natural polymers like Guar gum and Tara gum, individually and in combination in order to maintain MIN concentration in the blood over a period of time (24 hrs). Totally, seven formulations and in-vitro drug release studies were carried out in 0.1N HCl up to 2 hrs and in pH 7.4 buffer for remaining 22 hrs respectively. Based on the in-vitro drug release profiles, formulations F7 (combination of Guar and tara gum- 12.5%:12.5%) resulted in extended delivery of MIN (61.59%) for a period of 24 hours. Formualtion F6 containing guar gum at 37.5%w/w showed a 71.5 % release of MIN at the end of 24 hrs. Mathematical treatment of the in vitro drug release data suggests that, all the formulations fitted into first order release kinetics. Drug release from the matrix occurred by combination of two mechanisms, diffusion of drug from tablet matrix and anamolous transport, which was reflected from Higuchi's model and Korsmeyer peppas equation. Overall, combinatiomn of guar and tara gums significanlty slowed the release of MIN form tablets.

Keywords: Minocycline hydrochloride, Guar gum, Tara gum, extended release, matrix tablets.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia