EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

THE HYPOGLYCEMIC EFFECTS OF AQUEOUS LEAF EXTRACTS OF GONGRONEMA LATIFOLUM, PIPER NIGRUM AND SOLANUM MELONGENA ON BLOOD GLUCOSE LEVEL OF ALLOXAN-INDUCED DIABETIC GUINEA PIGS

Akunneh -Wariso C.* and Aduema W.

ABSTRACT

The aim of the study was evaluate the aqueous leaf extract of Gongronema latifolium (Utazi), Piper nigrum (Uziza) and Solanum melongena (Gardern egg) on blood sugar level of alloxan induced diabetic guinea pigs. Thirty -five guinea pigs of body weight (250-300g) of both male and female were randomly selected and grouped in to five groups. Each guinea pig was made diabetic by induction with a single dose of 5% alloxan monohydrate dissolved in 0.9% normal saline at 300mg/kg body weight intraperitoneally. Prior to administration, concentration of alloxan used for diabetic induction in these guinea pigs was determined during the preliminary test. The positive and negative control groups had oral administration of glibenclamide solution (a know oral hypoglycemic agent) at 0.25mg/day and 0.9% NS (a physiological solution) at 15ml/day via canula for two weeks respectively. The results of this study revealed appreciable percentage reduction of fasting blood sugar level of the diabetic guinea pigs that had oral administration of aqueous leaf extracts of Gongronema latifolium which was comparable to the fasting blood sugar level of positive control group (Glibernclamide solution), thereby showing an appreciable hypoglycemic effects. Similarly, the aqueous leaf extracts of Solanum melongena had a low percentage reduction which depicts mild hypoglycemic effects, while the group that had Piper nigrum showed a very insignificant percentage of reduction of mean fasting blood sugar which was comparable to the effect seen in negative control group. In conclusion, the z-test, as a statistical test revealed a significant difference between the post induction fasting blood sugar level and post aqueous leaf extract administration (p< 0.05).

Keywords: Gongronema latifolium (Utazi), Piper nigrum (Uziza) and Solanum melongena (Gardern egg).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)