EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A CLINICAL AND HISTOLOGICAL EVALUATION FOR THERAPEUTIC EFFICACY AND SAFETY OF TRANEXAMIC ACID LOCAL INFILTRATION WITH DERMAPEN IN COMBINATION WITH TOPICAL TRANEXAMIC ACID EMUGEL OR KLIGMAN’S FORMULA CREAM IN PATIENTS WITH MELASMA: A COMPARATIVE STUDY

Mohamed Abdalmoneim Shoaib M.D, Rehab Samaka M.D, Nada Farag Elnaidany M.D*, Azza Gaber Antar Farag and Mona Saber Aid M.B.B.Ch

ABSTRACT

Background: Tranexamic acid (TA), an anti-fibrinolytic lysine derivative, seems to be a promising agent for melasma treatment. But, little is known about its optimal administration route, dose, frequency, use duration, or its role in skin whitening of hypermelanotic patches. Aims and Objectives: To evaluate clinical and histological efficacy and safety of TA microinjection plus its topical use in treatment of melasma, and compare this lone use versus TA microinjection plus of Kligman’s formula. Materials and Methods: Egyptian melasma patients (n=40) were given TA(100 mg/mL per week) using dermapen for 12 weeks. Moreover, some patients used topical TA3% emulgel (group I, n=20), while others used Kligman’s formula (group II, n=20). Outcome measures were clinical assessment, Melasma Area and Severity Index (MASI) improvement percent, patient satisfaction and histopathological study including immunohistochemical staining. Results: At the end of 12th week, both groups showed a significant decrease in MSAI, that was more pronounced in group I (p=0.04), and significant improvement in pigmentation, solar elastosis, mast cell count and blood vessel density. No significant adverse effects were observed. Conclusion: Tranexamic acid (TA) is an effective and safe therapeutic agent for melasma treatment. Topical use of TA in between dermapen sessions has an improving consequence superior to that of Kligman’s formula.

Keywords: Tranexamic acid, Melasma, Dermapen, Kligman’s formula.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: MARCH ISSUE PUBLISHED

    MARCH 2024 issue has been successfully launched on MARCH 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia