PEROXISOME PROLIFERATOR- ACTIVATED RECEPTORS FAMILY OVERVIEW
Feryal Hashim Rada*
Nuclear receptor superfamily comprised of many receptors such as retinoic acid, thyroid hormone, steroid, and Peroxisome Proliferator- Activated Receptors (PPARs). The binding of Peroxisome Proliferator- Activated Receptor with its ligand and then with retinoid X receptor will lead to form a heterodimer complex, which has a transcription factors activity on many target PPAR responsive genes. The PPAR exist as three forms alpha (Î±), delta (Î´) and gamma (Î³) that have important roles in expression of gene that regulate many biological processes such as metabolism and deposition of lipid, metabolism of glucose, and reaction of inflammation.
Keywords: Peroxisome Proliferator- Activated Receptors (PPARs), vasoprotective, insulin sensitivity, inflammation.
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