FORMULATION AND EVALUTAION OF TOPICAL NANOSPONGE GEL FOR IMMUNOSUPPRESSIVE AGENT
*Chodvadiya Chandrika Upendra and Dr. Akruti S. Khodakiya
Two new topical immunosuppressive treatments, pimecrolimus and tacrolimus, were developed to provide
alternatives to topical corticosteroids without the associated adverse events. They work by inhibiting calcineurin in
the skin, which regulates the activity of several transcription factors that control cell division and trigger the early
stages of T cell activation. Topical tacrolimus inhibits experimentally induced allergic contact dermatitis, and
preliminary studies have suggested that the drug is effective in the treatment of atopic dermatitis.
Keywords: Topical Nanosponge gel, Tachrolimus, Immunosupressive agent.
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